Medically reviewed by Drugs. Last updated on Jan 7, Initial dose: 20 mg orally twice a day Maintenance dose: 60 mg per day, given either once a day or as 30 mg orally twice a day Maximum dose: mg orally per day Duration: Acute episodes generally require several months or more of sustained pharmacological therapy; a periodic review of the need for ongoing maintenance treatment and appropriate dosing is recommended.
Comments : -Some patients may require 30 mg orally once day for 1 week, before increasing the dose to 60 mg per day -Data are lacking to show that doses greater than 60 mg per day confer any additional benefits. Use: Treatment of major depressive disorder MDD. Initial dose: 30 mg orally once a day for 1 week Maintenance dose: 30 to 60 mg orally once a day Duration: Efficacy has been demonstrated for up to 3 months in placebo-controlled studies; effectiveness beyond this has not been demonstrated in longer studies; therefore, continued treatment should be based on individual patient response.
Comments : -There is no evidence that doses greater than 60 mg per day confer additional benefit; higher doses are associated with a higher rate of side effects. Initial dose: 60 mg orally once a day Maintenance dose: 60 to mg orally once a day Maximum dose: mg orally once a day Duration: Episodes generally require several months or more of sustained pharmacological therapy; a periodic review of the need for ongoing maintenance treatment and appropriate dosing is recommended.
Comments: -Some patients may require 30 mg orally once day for 1 week, before increasing the dose to 60 mg per day -The dose may be increased in increments of 30 mg once a day if clinically appropriate -There is no evidence that doses greater than 60 mg per day confer additional benefit. Initial dose: 30 to 60 mg orally once a day Maintenance dose: 60 mg orally once a day Duration : -Diabetic peripheral neuropathy pain: Efficacy beyond 12 weeks has not been established; effectiveness should be based on individual patient response.
Comments : -Some patients for whom tolerability may be a concern may require 30 mg orally once day for 1 week, before increasing the dose to 60 mg per day. Uses: Management of neuropathic pain associated with diabetic peripheral neuropathy; management of chronic musculoskeletal pain in patients with chronic low back pain and chronic pain due to osteoarthritis.
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